PUBLICATIONS
2025
Winters MT, Westemeier-Rice ES, Rawson TW, Patel KJ, Sankey GM, Dixon-Gross M, McHugh OR, Hashemipour N, Carroll ML, Wilkerson IR, Martinez I. SARS-CoV-2 Infection of Lung Epithelia Leads to an Increase in the Cleavage and Translocation of RNase-III Drosha; Loss of Drosha Is Associated with a Decrease in Viral Replication. Genes (Basel) 2025 Oct 20;16(10):1239. doi: 10.3390/genes16101239. PMID: 41153456. PMCID: PMC12564117.
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2024
Westemeier-Rice ES, Winters MT, Rawson TW, Patel KJ, McHugh O, Ward S, McLaughlin S, Stewart A, Misra B, Dziadowicz S, Yi W, Bobbala S, Hu G, Martinez I. Lnc-RAINY regulates genes involved in radiation susceptibility through DNA:DNA:RNA triplex-forming interactions and has tumor therapeutic potential in lung cancers. Noncoding RNA Res 2024 Dec 18:12:152-166. doi: 10.1016/j.ncrna.2024.12.004. eCollection 2025 Jun. PMID: 40235937. PMCID: PMC11999364.
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​Yazarlou F, Martinez I, Lipovich L. Radiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance. Front Oncol 2024 Sep 13:14:1437542. doi: 10.3389/fonc.2024.1437542. eCollection 2024. PMID: 39346726. PMCID: PMC11427263.
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Adjeroh DA , Zhou X, Paschoal AR, Dimitrova N, Derevyanchuk EG, Shkurat TP, Loeb JA, Martinez I, Lipovich L. Challenges in LncRNA Biology: Views and Opinions. Noncoding RNA 2024 Aug 1;10(4):43. doi: 10.3390/ncrna10040043. PMID: 39195572. PMCID: PMC11357347.
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Westemeier-Rice ES, Winters MT, Rawson TW, Martinez I. More than the SRY: The Non-Coding Landscape of the Y Chromosome and Its Importance in Human Disease. Noncoding RNA. 2024 Apr 10;10(2):21. doi: 10.3390/ncrna10020021. PMID: 38668379. PMCID: PMC11054740.
Taylor AD, Hathaway QA, Kunovac A, Pinti MV, Newman MS, Cook CC, Cramer ER, Starcovic SA, Winters MT, Westemeier-Rice ES, Fink GK, Durr AJ, Rizwan S, Shepherd DL, Robart AR, Martinez I, Hollander JM. Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase. Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C221-C236. doi: 10.1152/ajpcell.00648.2023. Epub 2024 Jun 3. PMID: 38826135.
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2023
Madajewski B, Boatman MA, Martinez I, Carter JH, Bey EA. NAD(P)H Quinone Oxidoreductase-1 Expression Promotes Self-Renewal and Therapeutic Resistance in Non-Small Cell Lung Cancer. Genes (Basel). 2023 Feb 28;14(3):607. doi: 10.3390/genes14030607. PMID: 36980879 PMCID: PMC10047941.
Lee SM , Winters MT, Martinez I, Slack FJ. Small regulatory RNAs: from bench to bedside - a keystone symposia meeting report. RNA Biol. 2023 Jan;20(1):136-139. doi: 10.1080/15476286.2023.2196046. PMID: 37016725 PMCID: PMC10078130.
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2022
Esposito R, Polidori T, Meise DF, Pulido-Quetglas C, Chouvardas P, Forster S, Schaerer P, Kobel A, Schlatter J, Kerkhof E, Roemmele M, Rice ES, Zhu L, Lanzos A, Guillen-Ramirez HA, Basile G, Carrozzo I, Vancura A, Ullrich S, Andrades A, Harvey D, Medina PP, Ma PC, Haefliger S, Wang X, Martinez I, Ochsenbein AF, Riether C, Johnson R. Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities. Cell Genomics. 2022 Sept 14; (2): 100171. doi: 10.1016/j.xgen.2022.100171.
Yu HG, Sizemore G, Martinez I, Perrotta P. Inhibition of SARS-CoV-2 Viral Channel Activity Using
FDA-Approved Channel Modulators Independent of Variants. Biomolecules. 2022 Nov 11; (12): 1673. doi: 10.3390/biom12111673.
Lee KS, Russ BP, Wong TY, Horspool AM, Winters MT, Barbier M, Bevere JR, Martinez I, Damron FH, Cyphert HA. Obesity and metabolic dysfunction drive sex-associated differential disease profiles in hACE2-mice challenged with SARS-CoV-2. iScience. 2022 Oct 21;25(10):105038. doi: 10.1016/j.isci.2022.105038. Epub 2022 Sep 2. PubMed PMID: 36068847; PubMed Central PMCID: PMC9436780.
Wong TY, Russ BP, Lee KS, Miller OA, Kang J, Cooper M, Winters MT, Rodriguez-Aponte SA, Dalvie NC, Johnston RS, Rader NA, Wong ZY, Cyphert HA, Martinez I, Shaligram U, Batwal S, Lothe R, Chandrasekaran R, Nagar G, Rajurkar M, Rao H, Bevere JR, Barbier M, Love JC, Damron FH. RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge. mSphere. 2022 Aug 31;7(4):e0024322. doi: 10.1128/msphere.00243-22. Epub 2022 Aug 15. PubMed PMID: 35968964; PubMed Central PMCID: PMC9429941.
Lee KS, Wong TY, Russ BP, Horspool AM, Miller OA, Rader NA, Givi JP, Winters MT, Wong ZYA, Cyphert HA, Denvir J, Stoilov P, Barbier M, Roan NR, Amin MS, Martinez I, Bevere JR, Damron FH. SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice. PLoS One. 2022;17(8):e0273430. doi: 10.1371/journal.pone.0273430. eCollection 2022. PubMed PMID: 36037222; PubMed Central PMCID: PMC9423646.
Barbier M, Lee KS, Vikharankar MS, Rajpathak SN, Kadam N, Wong TY, Russ BP, Cyphert HA, Miller OA, Rader NA, Cooper M, Kang J, Sen-Kilic E, Wong ZY, Winters MT, Bevere JR, Martinez I, Devarumath R, Shaligram US, Damron FH. Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2. Front Immunol. 2022;13:948431. doi: 10.3389/fimmu.2022.948431. eCollection 2022. PubMed PMID: 36091051; PubMed Central PMCID: PMC9450042.
Wong TY, Horspool AM, Russ BP, Ye C, Lee KS, Winters MT, Bevere JR, Miller OA, Rader NA, Cooper M, Kieffer T, Sourimant J, Greninger AL, Plemper RK, Denvir J, Cyphert HA, Barbier M, Torrelles JB, Martinez I, Martinez-Sobrido L, Damron FH. Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice. J Virol. 2022 Mar 23;96(6):e0218421. doi: 10.1128/jvi.02184-21. Epub 2022 Jan 26. PubMed PMID: 35080423; PubMed Central PMCID: PMC8941865.
Wong TY, Lee KS, Russ BP, Horspool AM, Kang J, Winters MT, Allison Wolf M, Rader NA, Miller OA, Shiflett M, Izac J, Varisco D, Sen-Kilic E, Cunningham C, Cooper M, Cyphert HA, Barbier M, Martinez I, Bevere JR, Ernst RK, Damron FH. Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge. NPJ Vaccines. 2022 Mar 14;7(1):36. doi: 10.1038/s41541-022-00451-7. PubMed PMID: 35288576; PubMed Central PMCID: PMC8921182.
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2021
McCall JL, Varney ME, Rice E, Dziadowicz SA, Hall C, Blethen KE, Hu G, Barnett JB, Martinez I. Prenatal Cadmium Exposure Alters Proliferation in Mouse CD4+ T Cells via LncRNA Snhg7. Front Immunol. 2021;12:720635. doi: 10.3389/fimmu.2021.720635. eCollection 2021. PubMed PMID: 35087510; PubMed Central PMCID: PMC8786704.
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Yekelchyk M, Madan E, Wilhelm J, Short KR, Palma AM, Liao L, Camacho D, Nkadori E, Winters MT, Rice ES, Rolim I, Cruz-Duarte R, Pelham CJ, Nagane M, Gupta K, Chaudhary S, Braun T, Pillappa R, Parker MS, Menter T, Matter M, Haslbauer JD, Tolnay M, Galior KD, Matkwoskyj KA, McGregor SM, Muller LK, Rakha EA, Lopez-Beltran A, Drapkin R, Ackermann M, Fisher PB, Grossman SR, Godwin AK, Kulasinghe A, Martinez I, Marsh CB, Tang B, Wicha MS, Won KJ, Tzankov A, Moreno E, Gogna R. Flower lose, a cell fitness marker, predicts COVID-19 prognosis. EMBO Mol Med. 2021 Nov 8;13(11):e13714. doi: 10.15252/emmm.202013714. Epub 2021 Oct 18. PubMed PMID: 34661368; PubMed Central PMCID: PMC8573598.
Horspool AM, Ye C, Wong TY, Russ BP, Lee KS, Winters MT, Bevere JR, Kieffer T, Martinez I, Sourimant J, Greninger A, Plemper RK, Denvir J, Cyphert HA, Torrelles J, Martinez-Sobrido L, Damron FH. SARS-CoV-2 B.1.1.7 and B.1.351 variants of concern induce lethal disease in K18-hACE2 transgenic mice despite convalescent plasma therapy. bioRxiv. 2021 May 5;. doi: 10.1101/2021.05.05.442784. PubMed PMID: 33972945; PubMed Central PMCID: PMC8109207.
He Z, Liu X, Wu F, Wu S, Rankin GO, Martinez I, Rojanasakul Y, Chen YC. Gallic Acid Induces S and G2 Phase Arrest and Apoptosis in Human Ovarian Cancer Cells In Vitro. Appl Sci (Basel). 2021 May 1;11(9). doi: 10.3390/app11093807. Epub 2021 Apr 23. PubMed PMID: 34386269; PubMed Central PMCID: PMC8356902.
Horspool AM, Kieffer T, Russ BP, DeJong MA, Wolf MA, Karakiozis JM, Hickey BJ, Fagone P, Tacker DH, Bevere JR, Martinez I, Barbier M, Perrotta PL, Damron FH. Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection. mSphere. 2021 Jan 20;6(1). doi: 10.1128/mSphere.01324-20. PubMed PMID: 33472985; PubMed Central PMCID: PMC7845617.
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2020
Hathaway QA, Taylor AD, Kunovac A, Pinti MV, Newman MS, Cook CC, Winters MT, Westemeier E, Fink GK, Durr AJ, Shepherd DL, Robart AR, Martinez I, Hollander JM. Mitochondrial Import of Malat1 Regulates Cardiac Mitochondrial Function in Type 2 Diabetes Mellitus through Interaction with MicroRNA-23b. Research Square. 2020 December 16;. doi: 10.21203/rs.3.rs-127504/v1. https://orcid.org/0000-0001-8226-2319.
He Z, Wu S, Lin J, Booth A, Rankin GO, Martinez I, Chen YC. Polyphenols Extracted from Chinese Hickory (Carya cathayensis) Promote Apoptosis and Inhibit Proliferation through the p53-Dependent Intrinsic and HIF-1α-VEGF Pathways in Ovarian Cancer Cells. Appl Sci (Basel). 2020 Dec 1;10(23). doi: 10.3390/app10238615. PubMed PMID: 33520293; PubMed Central PMCID: PMC7842596.
Brownmiller T, Juric JA, Ivey AD, Harvey BM, Westemeier ES, Winters MT, Stevens AM, Stanley AN, Hayes KE, Sprowls SA, Ammer ASG, Walker M, Bey EA, Wu X, Lim ZF, Zhu L, Wen S, Hu G, Ma PC, Martinez I. Y Chromosome LncRNA Are Involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells. Cancer Res. 2020 Oct 1;80(19):4046-4057. doi: 10.1158/0008-5472.CAN-19-4032. Epub 2020 Jul 2. PubMed PMID: 32616503; PubMed Central PMCID: PMC7541653.
2015-2019
Barr JA, Hayes KE, Brownmiller T, Harold AD, Jagannathan R, Lockman PR, Khan S, Martinez I. Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells. Sci Rep. 2019 Mar 6;9(1):3662. doi: 10.1038/s41598-019-40094-8. PubMed PMID: 30842470; PubMed Central PMCID: PMC6403315.
Hayes KE, Barr JA, Xie M, Steitz JA, Martinez I. Immunoprecipitation of Tri-methylated Capped RNA. Bio Protoc. 2018 Feb 5;8(3). doi: 10.21769/BioProtoc.2717. PubMed PMID: 29527542; PubMed Central PMCID: PMC5842925.
Shepherd DL, Hathaway QA, Pinti MV, Nichols CE, Durr AJ, Sreekumar S, Hughes KM, Stine SM, Martinez I, Hollander JM. Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase). J Mol Cell Cardiol. 2017 Sep;110:15-25. doi: 10.1016/j.yjmcc.2017.06.012. Epub 2017 Jul 11. PubMed PMID: 28709769; PubMed Central PMCID: PMC5854179.
Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D. An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4961-E4970. doi: 10.1073/pnas.1618732114. Epub 2017 Jun 5. PubMed PMID: 28584122; PubMed Central PMCID: PMC5488920.
Moses BS, Evans R, Slone WL, Piktel D, Martinez I, Craig MD, Gibson LF. Bone Marrow Microenvironment Niche Regulates miR-221/222 in Acute Lymphoblastic Leukemia. Mol Cancer Res. 2016 Oct;14(10):909-919. doi: 10.1158/1541-7786.MCR-15-0474. Epub 2016 Jun 29. PubMed PMID: 27358112; PubMed Central PMCID: PMC5065748.
Jagannathan R, Thapa D, Nichols CE, Shepherd DL, Stricker JC, Croston TL, Baseler WA, Lewis SE, Martinez I, Hollander JM. Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic Heart. Circ Cardiovasc Genet. 2015 Dec;8(6):785-802. doi: 10.1161/CIRCGENETICS.115.001067. Epub 2015 Sep 16. PubMed PMID: 26377859; PubMed Central PMCID: PMC4681669.
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2010-2014
Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. Aging (Albany NY). 2014 Mar;6(3):160-75. doi: 10.18632/aging.100643. PubMed PMID: 24659628; PubMed Central PMCID: PMC4012934.
Unlu S, Tang S, Wang E, Martinez I, Tang D, Bianchi ME, Zeh HJ 3rd, Lotze MT. Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells. PLoS One. 2012;7(6):e38899. doi: 10.1371/journal.pone.0038899. Epub 2012 Jun 22. PubMed PMID: 22745684; PubMed Central PMCID: PMC3382181.
Martinez I, Dimaio D. B-Myb, cancer, senescence, and microRNAs. Cancer Res. 2011 Aug 15;71(16):5370-3. doi: 10.1158/0008-5472.CAN-11-1044. Epub 2011 Aug 9. Review. PubMed PMID: 21828240; PubMed Central PMCID: PMC3156249.
Martinez I, Almstead LL, DiMaio D. MicroRNAs and senescence. Aging (Albany NY). 2011 Feb;3(2):77-8. doi: 10.18632/aging.100282. PubMed PMID: 21304181; PubMed Central PMCID: PMC3082014.
Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D. miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):522-7. doi: 10.1073/pnas.1017346108. Epub 2010 Dec 27. PubMed PMID: 21187425; PubMed Central PMCID: PMC3021067.
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1998-2007
Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, Khan SA. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17;27(18):2575-82. doi: 10.1038/sj.onc.1210919. Epub 2007 Nov 12. PubMed PMID: 17998940; PubMed Central PMCID: PMC2447163.
Martinez I, Wang J, Hobson KF, Ferris RL, Khan SA. Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Eur J Cancer. 2007 Jan;43(2):415-32. doi: 10.1016/j.ejca.2006.09.001. Epub 2006 Oct 31. PubMed PMID: 17079134; PubMed Central PMCID: PMC1847595.
Ferris RL, Martinez I, Sirianni N, Wang J, López-Albaitero A, Gollin SM, Johnson JT, Khan S. Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis. Eur J Cancer. 2005 Mar;41(5):807-15. doi: 10.1016/j.ejca.2004.11.023. PubMed PMID: 15763658.
Martínez I, Mantilla A, Medrano ME, Hernández R, Hernández DM, Lazos M, Santiago H, González B, Hidalgo A, Salcedo M. High prevalence of RET tyrosine kinase activation in Mexican patients with papillary thyroid carcinomas. Endocr Pathol. 2001 Summer;12(2):113-23. doi: 10.1385/ep:12:2:113. PubMed PMID: 11579677.
Hidalgo A, Medrano ME, Rodrìguez S, Franco C, Martinez I, Benítez L, Salcedo M. Presence of the 918 mutation in the RET proto-oncogene in a Mexican patient with multiple endocrine neoplasia type 2B. J Exp Clin Cancer Res. 1998 Jun;17(2):149-52. PubMed PMID: 9700574.